Does erythropoietin slow progression of chronic kidney disease?
نویسندگان
چکیده
*Corresponding author: Ali Ghorbani, Department of Nephrology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. E-mail: [email protected] Implication for health policy/practice/research/medical education: The initiation of erythropoietin therapy for the purpose of renoprotection may need to be sooner than that for erythropoiesis, because erythropoietin may attenuate renal fibrosis through macrophage adjustment and endothelial cell protection by other uncertain mechanisms. Although, agents re-establishing the initial function of renal erythropoietin-producing cells could defer kidney fibrosis, however more studies should be carried out to determine the cellular target of erythropoietin in kidney and developinga new erythropoietin derivative for renal care.
منابع مشابه
پیشبینی مقدار تجویز داروی اریتروپویتین در بیماران همودیالیزی- رویکرد دادهکاوی
Background and purpose: Kidney failure reduces the kidney function and in long term it leads to chronic kidney disease. One of the main complications of this disease is irreversible damage to the kidneys (end-stage kidney disease) and hemodialysis is the main method used to treat advanced kidney failure. The main problem associated with hemodialysis is treating anemia caused by lack of erythrop...
متن کاملThe influence of the pleiotropic action of erythropoietin and its derivatives on nephroprotection
Erythropoietin (EPO) is traditionally described as a hematopoietic cytokine or growth hormone regulating proliferation, differentiation, and survival of erythroid progenitors. The use of EPO in patients with chronic kidney disease (CKD) was a milestone achievement in the treatment of anemia. However, EPO involves some degree of risk, which increases with increasing hemoglobin levels. A growing ...
متن کاملNon-albuminuric Diabetic Kidney Disease in Diabetic Patients: A Review
Introduction: The constantly increasing incidence of type 2 diabetes, probably due to obesity and sedentary life, has led to the increased incidence of macro- and microvascular diabetic complications such as nephropathy. Despite the prompt efforts to develop effective treatments for diabetes and slow the progression of its complications, it is still reported as the most common cause of chronic ...
متن کاملInflammation and poor response to treatment with erythropoietin in chronic kidney disease Authors
Chronic kidney disease (CKD) is a serious public health problem and its incidence has increased in recent years. It is progressive and is associated with high morbidity and mortality rates.1 There are several conditions associated with CKD onset and progression. We stress the following: obesity, hypertension and diabetes mellitus. In addition to these conditions, there are signs of inflammation...
متن کاملRenal Cell Protection of Erythropoietin beyond Correcting The Anemia in Chronic Kidney Disease Patients
Currently many patients with chronic renal failure have profited from the use of erythropoietin to correct anemia (1,2). In chronic kidney disease, anemia is believed to be a surrogate index for tissue hypoxia that continues preexisting renal tissue injury (1-3). Erythropoietin is an essential glycoprotein that accelerates red blood cell maturation from erythroid progenitors and facilitates ery...
متن کامل